3D printed fluidic platform with in-situ covalently immobilized polymer monolithic column for automatic solid-phase extraction

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dc.contributor.author Correa-Carrasco, Enrique J.
dc.contributor.author Cocovi-Solberg, David J.
dc.contributor.author Herrero-Martínez, José M.
dc.contributor.author Simó-Alfonso, Ernesto F.
dc.contributor.author Miró, Manuel
dc.date.accessioned 2021-10-25T05:15:07Z
dc.date.available 2021-10-25T05:15:07Z
dc.identifier.uri http://hdl.handle.net/11201/155921
dc.description.abstract [eng] In this work, 3D stereolithographic printing is proposed for the first time for the fabrication of fluidic devices aimed at in-situ covalent immobilization of polymer monolithic columns. Integration in advanced flow injection systems capitalized upon programmable flow was realized for fully automatic solid-phase extraction (SPE) and clean-up procedures as a 'front-end' to on-line liquid chromatography. The as-fabricated 3D-printed extraction column devices were designed to tolerate the pressure drop of forward-flow fluidic systems when handling large sample volumes as demonstrated by the determination of anti-microbial agents, plastic additives and monomers as models of emerging contaminants (4-hydroxybenzoic acid, methylparaben, phenylparaben, bisphenol A and triclosan). Decoration of the monolithic phase with gold nanoparticles (AuNPs) was proven most appropriate for the enrichment of phenolic-type target compounds. In particular, the absolute recoveries for the tested analytes ranged from 73 to 92% both in water and saliva samples. The 3D printed composite monolith showed remarkable analytical features in terms of loading capacity (2 mg g−1), breakthrough volume (10 mL), satisfactory batch-to-batch reproducibility (<9% RSD), and easy on-line coupling of the SPE device to HPLC systems. The fully automatic 3D-printed SPE-HPLC hyphenated system was also exploited for the on-line extraction, matrix clean-up and determination of triclosan in 200 μL of real saliva samples.
dc.format application/pdf
dc.relation.isformatof Versió postprint del document publicat a: https://doi.org/10.1016/j.aca.2020.03.033
dc.relation.ispartof Analytica Chimica Acta, 2020, vol. 1111, p. 40-48
dc.rights (c) Elsevier B.V., 2020
dc.subject.classification 54 - Química
dc.subject.other 54 - Chemistry. Crystallography. Mineralogy
dc.title 3D printed fluidic platform with in-situ covalently immobilized polymer monolithic column for automatic solid-phase extraction
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion
dc.date.updated 2021-10-25T05:15:08Z
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.1016/j.aca.2020.03.033

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