Microextraction approaches for bioanalytical applications: An overview

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dc.contributor.author Abdel-Rehim, Mohamed
dc.contributor.author Pedersen-Bjergaard, Stig
dc.contributor.author Abdel-Rehim, Abbi
dc.contributor.author Lucena, Rafael
dc.contributor.author Mahdi Moein, Mohammad
dc.contributor.author Cárdenas, Soledad
dc.contributor.author Miró, Manuel
dc.date.accessioned 2021-10-25T07:16:53Z
dc.date.available 2021-10-25T07:16:53Z
dc.identifier.uri http://hdl.handle.net/11201/155945
dc.description.abstract [eng] Biological samples are usually complex matrices due to the presence of proteins, salts and a variety of organic compounds with chemical properties similar to those of the target analytes. Therefore, sample preparation is often mandatory in order to isolate the analytes from troublesome matrices before instrumental analysis. Because the number of samples in drug development, doping analysis, forensic science, toxicological analysis, and preclinical and clinical assays is steadily increasing, novel high throughput sample preparation approaches are calling for. The key factors in this development are the miniaturization and the automation of the sample preparation approaches so as to cope with most of the twelve principles of green chemistry. In this review, recent trends in sample preparation and novel strategies will be discussed in detail with particular focus on sorptive and liquid-phase microextraction in bioanalysis. The actual applicability of selective sorbents is also considered. Additionally, the role of 3D printing in microextraction for bioanalytical methods will be pinpointed.
dc.format application/pdf
dc.relation.isformatof Versió postprint del document publicat a: https://doi.org/10.1016/j.chroma.2019.460790
dc.relation.ispartof Journal of Chromatography A, 2020, vol. 1616, num. 460790, p. 1-15
dc.subject.classification 54 - Química
dc.subject.other 54 - Chemistry. Crystallography. Mineralogy
dc.title Microextraction approaches for bioanalytical applications: An overview
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/acceptedVersion
dc.date.updated 2021-10-25T07:16:54Z
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.identifier.doi https://doi.org/10.1016/j.chroma.2019.460790


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