Relationship between atherogenic dyslipidemia and lipid triad with scales that assess non alcoholic liver disease in 418,343 spanish workers

Abstract

[eng] Background: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent hepatic pathology in the world today. Different biochemical processes are involved in NAFLD thus, in steatosis there is an accumulation of triglycerides in the hepatocytes. NAFLD is associated with alterations in lipoprotein metabolism similar to the atherogenic dyslipidemia (AD) observed in conditions with insulin resistance, such as obesity and diabetes. The aim of this study was to determine the relationship between AD and lipid triad (LT) and different risk scales for NAFLD in a group of Spanish workers. Methods: A descriptive, cross-sectional study in 418,343 Spanish workers, in which different anthropometric parameters, different risk scales for NAFLD, AD and LT were evaluated. And we have proceeded to relate these last two parameters with the different NAFLD formulas. In the univariate analysis, the t- student test was used, when the variables were quantitative, calculating the mean and the standard deviation. When the variables were qualitative, the chi-square test was applied and the prevalences were calculated. The possible usefulness of the NAFLD risk scales to be able to predict the appearance of AD and LT was assessed using ROC curves, obtaining the area under the curve (AUC) and the cut-off points. Results: The mean values of all the NAFLD risk scales used show higher values in persons with AD and LT, both in men and in women. In the analysis of the ROC curves, we found that all the formulas used to assess the risk of fatty liver present a good AUC in both sexes, both for predicting AD and for the LT, with the exception of the HSI, which presents an AUC that would be evaluated as regular. Conclusions: There are higher mean values and prevalence of elevated values for all different NAFLD risk scales in persons with AD and LT.