Suicidal risk and executive functions in major depressive disorder: a study protocol

Show simple item record Roca, M. Riera-López del Amo A. Riera-Serra, P. Pérez-Ara, M.A. Castro, A. Roman-Juan, J. García-Toro, M. García-Pazo, P. Gili, M. 2024-02-01T12:03:57Z 2024-02-01T12:03:57Z
dc.description.abstract Background: Suicide is a serious public health concern. Depression is the main gateway to suicidal behavior. The already established relationship between depression and suicidal risk should now focus on the investigation of more specific factors: recent studies have suggested an association between vulnerability to suicidal behavior and neurocognitive alterations, a nuclear symptom of depression. This project aims to identify alterations in the Executive Functions (EF) of patients suffering a first depressive episode that might constitute a risk factor for suicidal ideation, suicidal attempts and suicide, to allow for more adequate suicide prevention. Methods: Prospective longitudinal design involving two groups (first depressive episodes with and without alterations in their EF) and four repeated measures (0, 6, 12 and 24months). The estimated minimum sample size is 216 subjects. The variables and measurement instruments will include socio-demographic variables, clinical variables (age of illness onset, family and personal antecedents, psychopathological and medical comorbidity, suicidal ideation, suicide attempts and completed suicides, severity of depression, including melancholic or atypical, remission of the depressive episode), and neuropsychological variables (EF and decision-making processes evaluated through the Cambridge Neuropsychological Test Automated Battery (CANTAB)). Discussion: First and foremost, the identification of clinical and neuropsychological risk factors associated with suicidal behavior will open the possibility to prevent such behavior in patients with a first depressive episode in the context of clinical practice. Secondly, interventions aimed at cognitive impairment (in particular: EF) derived from the study may be incorporated into strategies for the prevention of suicidal behavior. Finally, impaired neurocognitive function (even in early stages) could become an identifiable endophenotype or 'marker' in clinical and neurobiological studies about suicidal behavior in depressive patients. Keywords: Major depressive disorder, Suicide, Suicidal attempt, Suicidal ideation, Executive functions, Longitudinal study
dc.format application/pdf
dc.relation.isformatof Reproducció del document publicat a:
dc.relation.ispartof Bmc Psychiatry, 2019, vol. 19, p. 253
dc.rights cc-by (c) Roca, M. et al., 2019
dc.subject.classification 159.9 - Psicologia
dc.subject.classification Ciències de la salut
dc.subject.classification 61 - Medicina
dc.subject.other 159.9 - Psychology
dc.subject.other Medical sciences
dc.subject.other 61 - Medical sciences
dc.title Suicidal risk and executive functions in major depressive disorder: a study protocol
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion 2024-02-01T12:03:58Z
dc.subject.keywords Suicidio
dc.subject.keywords Depresión Mayor
dc.subject.keywords neuropsicología clínica
dc.rights.accessRights info:eu-repo/semantics/openAccess

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cc-by (c) Roca, M. et al., 2019 Except where otherwise noted, this item's license is described as cc-by (c) Roca, M. et al., 2019

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